CLEVELAND (AP) — Travis Hafner hit a two-out, two-run homer in the ninth inning off Seattle closer Brandon League on Friday night, rallying the Cleveland Indians to their latest dramatic win, 5-4 over the Mariners, who lost their sixth straight.

Hafner belted an 0-1 pitch from League (0-4) over the center-field fence for his first homer since April 17, sending a crowd of 33,774 into a frenzy.

After Hafner was mobbed near home plate by his teammates, he leaped into second baseman Orlando Cabrera's arms and the crowd sang "Cleveland Rocks" as fireworks exploded overhead.

Tony Sipp (2-0) pitched a perfect 1 1-3 innings for the win.

It was Cleveland's ninth last at-bat win in a season growing more surprising by the day.

Hafner's homer spoiled Seattle manager Eric Wedge's homecoming in Cleveland and was yet another punch-in-the-gut loss for the Mariners, who have lost three of their last four on walk-off hits.

After being held in check by Seattle starter Doug Fister for eight innings, the Indians entered the ninth trailing 4-2 and about to disappoint their second-largest crowd this season.

But Michael Brantley opened the ninth with a double into the gap in left-center, and Asdrubal Cabrera followed with an RBI double over the head of rookie left fielder Carlos Peguero, who seemed to freeze on the hard hit that was right at him.

Shin-Soo Choo's groundout moved Cabrera to third, and he stayed there when Carlos Santana grounded out to second.

Up came Hafner, who had struck out looking in his previous at-bat in the seventh. He looked at a fastball for strike one before driving League's second pitch over the wall.

Choo and Brantley also homered for the Indians, now a stunning 24-13 and believing they can stay in contention all season.

Justin Smoak hit a two-run homer for Seattle and Peguero hit his first major league homer, a 422-foot solo shot.

Although he's not likely to admit it, the stoic-and-steady Wedge had to be stung by the loss. He managed the Indians for seven seasons, guiding them through a tough rebuilding period and leading them to just one playoff appearance in 2007, when they missed the World Series by one win.

Wedge, who was never embraced by Cleveland fans, was fired after losing 97 games in 2009.

Fister was supposedly a break for the Indians, who have been facing some of the AL's top pitchers recently. In 12 games leading into the series opener, Cleveland had gone against seven pitchers ranked in the top 20 in ERA in the league.

Fister looked as if he belonged there.

Other than giving up the homers, he was in command. Fister retired the side in order in four innings, and he faced only three batters in the second, when the Mariners turned a double play. But when Wedge turned things over to League, the Mariners struggled.

Down 2-1, the Mariners scored three in the seventh, highlighted by Smoak's homer.

The Mariners didn't hit anything hard for four-plus innings against Fausto Carmona, who didn't allow a hit for the first 4 2-3 innings.

Peguero changed that in a hurry.

The free-swinging 24-year-old Dominican, whom the Mariners believe can one day be a slugger, drove Carmona's first pitch deep into the seats in right. The 6-foot-5, 245-pounder showed good pop — when he made contact — in the minors, hitting 54 homers the past two seasons. However, he was strikeout prone, fanning 350 the past two years.

For the third straight game, the Indians played without center fielder Grady Sizemore, who is resting a bruised right knee. Sizemore did some light drills — he played catch and hit off a tee — and the Indians are being extra cautious with the 28-year-old, who underwent season-ending surgery on his left knee last June.

Choo gave the Indians a 1-0 lead in the first with his fifth homer, and Brantley's homer made it 2-0 in the third.

Notes: The Mariners are hoping rest and a rehab program will help closer David Aardsma overcome a strained elbow ligament. Aardsma, who has not pitched this season after undergoing hip surgery in January, has been told he will not need Tommy John surgery. ... LHP Jason Vargas on Thursday became the first Mariner to pitch nine shutout innings in a no-decision since Indians pitching coach Tim Belcher did it for Seattle on June 4, 1994. ... In 511 games in the minors, Peguero struck out 660 times. ... At 6-foot-8, Fister is the second-tallest pitcher in Mariners history. Only 6-10 Randy Johnson was taller.